Why Thiamine 150mg
- Thiamine, in normal healthy cells, facilitates hundreds of different reactions.
- One of those reactions involves an enzyme called Pyruvate Dehydrogenase, or PDH.
- Each of your cells has a “powerhouse”– the part that produces energy– called the mitochondria. When PDH is functioning normally, cells use oxygen to produce energy; that process (oxidative phosphorylation) takes place in the mitochondria.
- Cells are fed their oxygen by your blood vessels, which carry the oxygen from the lungs throughout the body. If cells grow too fast, and outstrip their normal blood supply, they die. However, certain damaged cells have been known to inactivate their PDH enzyme. If PDH is inactive, cells can sometimes create energy without oxygen, using a process called glycolysis.4 That means that large bunches of cells that have outstripped their blood supply can find a way to survive even though they aren’t getting much oxygen. That is not a good thing for we humans. It means normal cellular apoptosis has been bypassed. We want the normal, healthy function of PDH to be maintained. We want our cells to get their energy from oxygen, not from glycolysis.
- Thiamine (Vitamin B1) can maintain the function of PDH and keep the cell running on oxygen—but thiamine only does this when given in high doses, over 100 times the Recommended Daily Allowance.1,3
- The amount of thiamine used in multivitamins (generally around 50mg) is not enough to accomplish this.
For that reason, Curos Essential has 150mg of thiamine: 125 times the U.S. RDA. Thiamine is certainly safe at 150mg per day; it has been found to be safe in humans using up to 7,500mg per day for many months– fifty times the amount in Curos Essential.1,2