Selenium is involved in expression of detoxification proteins as well as genes that control apoptosis.1 (For more on apoptosis, see our tocotrienol page or this Wikipedia page.) The selenium they chose was not Seleno-methionine, which is what most supplements use. Rather, it was a type of selenium from Saccharomyces cerevisiae yeast. Participants took 200mcg per day of this particular form of selenium (exactly what is in Curos Essential), for about 4.5 years.
The results of the NCI study were pretty impressive.
There have been other studies on different types of selenium, with inconsistent results. Some possible reasons for this:
- It’s not clear whether seleno-methionine yields the same results as selenium from yeast. There are differences in the proteins expressed in selenium-enriched yeast compared to selenomethionine6,7,8
- Selenium may have more benefit
- The benefit may be greatest in people who have low selenium levels to begin with.
Basic science research does show selenium supports apoptosis, cell cycle arrest, and detoxification.8
Including this ingredient in Curos Essential was an easy decision, for three reasons:
1. It is safe (like all of our ingredients, it has GRAS designation)
2. We mimicked both the dose (200mcg) and types used in the best human study to date, as noted above.
3. This ingredient is helpful in maintaining normal healthy thyroid function, particular in patients taking iodine in doses above 1mg per day. We anticipate iodine in milligram dosages will be part of future Curos offerings, and we wanted all of the support nutrients to be in Curos Essential. We also believe that in many parts of the U.S., the soil is depleted of minerals that used to be available in our food, and therefore supplementing with some minerals may be beneficial. For more on the topic of soil micronutrient depletion, see this paper.