What Does Healthy Cellular Function Mean?
Healthy Cellular Function:
Healthy cellular functions are the root of all health. Your body is made up of billions of cells, science tells us very clearly what nutrients your cells need to maintain optimal health. We also know from science what can impact the health of your cells, from chemical toxins to genetics. The objective in maintaining healthy cellular functions is to enable your cells (regardless of what their individual responsibility is) to function at their optimal level.
We can think about this in very simple terms. If we are made up of billions of the tiny little biological machines (aka cells) it stands to reason that if each of those tiny machines is operating as close to perfect as possible, the whole system will feel better, look better and operate better. Makes sense, right?
Interviewer (David Goldberg): Hey guys. So really excited to be back here with Dr. Josh Trutt, chief medical officer here at [inaudible], and we’re gonna talk about a really complex subject today. We’re gonna talk about what it actually means to stay healthy and how our bodies are trying to stay healthy, and I’ll preface it by saying that we are really complex organisms and I’m learning more and more health complex and all the variables that go into it. We’re never going to be able to address it all on this one video. So we’re gonna address some concepts and we’re gonna try to dive in where we can, but in other videos we’ll go into greater depth, and we’ll learn more about what’s actually going on. So one of the things that keeps coming up in my world is this idea of healthy cellular function. And I guess my question for you is, what’s keeping our cells from doing their job? Like, why do we have to talk about healthy [inaudible] aren’t they healthy?
Interviewee (Dr. Josh Trutt): Right. So we’re used to thinking of our body on a macro level. Your liver and that’s doing detoxification you have your heart and that’s pumping the blood, your lung sort of processing the oxygen. So we understand if you have a disease of one of those organs that are that process breaks down, but really all of those organs are made up of billions and billions of tiny cells, and they have to each be able to do their job. So when we talk about taking in toxins and dealing with toxicity, it’s actually at the cellular level that things are breaking down first. And you ask, what keeps them from doing their job? So I just kind of mentioned a few of the organs that are in our body where actually ourselves also have organs, we call them organelles, tiny organs and to two of the important, ones one is the mitochondria which are the energy, the powerhouse of ourselves. So the mitochondria is like our engine room, and its job is to make something called ATP, which is the unit of energy that our cells to do everything. Without ATP, life is over. And without ATP within one cell that cell’s life is over and if it can’t make weight enough ATP, then that cell is alive but compromise, right? And so disease and also aging just like breaking down that happens with aging is the process of, happens when ourselves are no longer able to make enough energy to do their job. So that’s number one. Number 2, another organelle that’s in there it’s called the nucleus, and the nucleus contains our DNA, and DNA is the instruction manual for the cell for everything that it needs to do, all the proteins that it needs to make are contained in the instruction manual. So the concern is, what happens if the DNA gets damaged, and that’s really what we’re talking about when we talk about toxicity. When we whether it’s from the sun’s rays, damage from the sun’s rays, that’s causing DNA damage and the instruction manual gets messed up and the cell isn’t sure how to proceed or proceeds in a way that’s dangerous for the rest of the body.
David: And we can both be born with those some damage to that guide book refer to how we’re in our DNA supposed to function through our genetics, and then as I’m learning more and more especially from you about the fact that there’s also this idea of epigenetics, that’s our lifestyle in our environment. So we actually can be impacting both for positive and for negative at least at the genetic factor, is that true?
Dr. Trutt: Sure, yes epigenetics is going to become a bigger and bigger topic, it has been steadily gaining speed over the past 20 years, and it’s another way of thinking about environment, nurture. So we used to say nature versus nurture, right? And now we’re talking a little bit about nature versus epigenetics, which means things that happen in our environment that affect our genes and affect their ability to give the proper instructions.
David: Which could be what we’re eating or you said the sun’s rays or radiation or toxins from living next to some sort of factory or something, it could literally be almost anything.
Dr. Trutt: Right.
David: So we’re not gonna be able to dive into that, because those are big concepts, but important kind of framework to understand, and I guess [04:38 crosstalk].
Dr. Trutt: [cross talk] is that aside from toxicity which we just discussed, where your body also has the need to make like 200 billion new cells every day, just to keep things going, keep things running, and that means that’s a lot of DNA that it has to copy for the next cell, and if you’re copying 200 billion cells worth of DNA, that’s a lot of opportunity to make some mistakes. So that’s another way that DNA damage happens is in the natural process of cell replication, and in some of the natural cell functions that it has to do, there are opportunities in there which we won’t get into it for DNA to be damaged. So your body has that ways to repair that.
David: So our cells, is it fair to say that our cells replicate, because they want to produce a younger healthier version of itself?
Dr. Trutt: Yeah. Well in some cases they’re replicating because you’ve damaged your skinning and you need to produce more to heal the wound. We need to create new blood cells. So yes, it’s creating it’s replenishing what gets lost.
David: And so what systems do we have to support that process of replication, as you said 200 billion cells a day is a lot, right?
Dr. Trutt: Right. So we there are a few things that our bodies do. First of all we have a DNA repair system in place and it’s pretty effective it gets at least 99% of the mistakes that are made probably more, but occasionally a mistake will slip through. Also we have a detoxification system in place where we’re able to neutralize toxins that are coming into our body in order to prevent DNA damage from occurring in the first place. If those fail, and cells do get damaged, we use a process called Cell Cycle Arrest, so instead of replicating instead of the cell cycle of life you have replication, we stop, we put hit pause and wait and say, listen this cell is damaged, think of it like getting a flat tire, right? So if you have a flat tire you realize, hey, I have some damage to my tire, I’m not gonna keep driving whereas I’ll get further damage to the rest of the car, I’m gonna pull over. So that Cell Cycle Arrest, you pull over and repair the to the flat and then you can keep going, right? The next layer after that is what happens if you have too much damage and you can’t repair it, right? It’s beyond the capability of your cell to repair. So in that case you have another system of defense called Apoptosis and what that means is the cells around that cell or sometimes within that cell like it gives give it a signal, hey you have to stop replicating permanently, you have to essentially commit suicide to use it dramatic phrasing, and this is super common. Sixty billion cells in our body do that everyday.
David: So just, okay. So check-in, right? So basically what’s happening is, before our cell replicates, it stops itself it says, am I healthy to replicate, a flat tire scenario, if it’s able if it finds an issue and it can fix it, great, and it kind of goes on to the process, if it doesn’t find an issue or if there’s an issue that’s present but it can’t recognize it can go through this process called apoptosis word naturally expires and says I’m not gonna replicate myself because I’m too broken to continue.
Dr. Trutt: Right.
David: Okay, got it.
Dr. Trutt: And if that also fails, if the cell manages to bypass those mechanisms of apoptosis, which you know, by the way that’s that’s what happens in a tumor, it’s getting all these messages from the cells around it, hey, you need to stop replicating and it manages somehow to bypass that it doesn’t listen, right? So when that happens we have another sort of failsafe, your cells called natural killer cells, another dramatic term [08:41 crosstalk] and their job is to they’re kind of like bouncers, they go through your bloodstream and they’re looking for cells that really don’t belong anymore, and they will try to take them out of the system forcibly. Exactly.
David: Wow, and you know these are things that you introduce it back to me and you know and just as a layman, again it’s like the better that I can kind of understand what’s happening, it gives me such a better context for how I can impact it.
Dr. Trutt: Right, so these are the things we’re talking about when we’re talking about improving our cellular health means, what can you do to support Cell Cycle Arrest, Apoptosis, mitochondrial function that energy that runs the entire system. Those are all the things that we look to support and what we do.
David: And it makes sense, it makes sense that what we eat the nutrients that those functions need to do their job. It has a big impact, like if we’re eating donuts every day, if those things are just not gonna be able to do their job as well as it could. It could be like filling your car not with engine oil but with sugar. Quite literally sugar. And you know that to me is one of the things that’s so interesting just kind of about what we’re seeing in the Wellness space in general again as a layman is well there’s a lot of opportunities that we now have to eat better, and to supplement our diet with the things that science is telling us those functions need to function, right? So that’s one of those other things that to me is amazing is holds this science there and there’s more science being delivered every day, and there’s such an incredible opportunity to use that, real science peer review real science to help us understand how we can be doing a better job of staying healthy, and we’re gonna address a lot of these concepts moving forward. It’s a lot, we want you guys really healthy. I know I want to be healthy, I know you want to be healthy. I know you work every day to keep your patients healthy and I appreciate you just taking a moment to kind of talk through this and hopefully we’ll be able to share a lot more, and if you guys have any questions or anything that we can help address, leave a note in the comments and we’ll go from there but Dr. Trutt thank you very much and I’ll talk to you guys soon you.